Dr. Cella has several grants and contracts to study questions regarding quality of life measurement in clinical trials, cross-cultural equivalence of quality of life measurement, efficacy of psychosocial interventions in oncology, and medical outcomes research. He has developed and is continually refining the Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System for outcome evaluation in patients with chronic medical conditions. He is principal investigator of the statistical coordinating center for the NIH Roadmap Initiative to build a Patient Reported Outcome Measurement Information System (PROMIS). He is also principal investigator of a contract to develop item banks for the clinical trials supported by the National Institute of Neurological Disorders and Stroke.