Principal Investigator:  Julie A. Kreyenbuhl, Pharm. D., Ph.D. 

Funded by:  R34MH094555-01

Up to 60% of individuals with schizophrenia do not take their antipsychotic medications as prescribed, which can lead to symptom relapse, decreased functioning, hospitalization, and increased healthcare costs. A variety of internet- and mobile phone-based applications have been developed to improve health outcomes, such as medication adherence, for a number of medical and psychiatric disorders. However, no such applications have been developed for individuals with schizophrenia. We will develop and test an ecological momentary intervention (EMI), which is integrated into an individual's daily life to improve antipsychotic adherence. Primary features of the EMI that will be installed on mobile SmartPhones include: an interactive tool that provides individuals reminders to take their medications as prescribed, asks them about their intent to take their medication or not, collects real-time psychiatric symptom and side effect data that can be view by themselves as well as by their clinicians, and provides them with the capability of communicating with their clinicians about problems they may be experiencing with their medications. Our goal for the EMI is to evaluate if there is an improvement in antipsychotic adherence as well as if the individuals' psychotic symptoms and neuropsychological functioning correlate with the use of the program and its overall acceptability by individuals. Completion of this developmental study will enable us to develop and refine the research strategies to be utilized in a subsequent larger-scale study of the intervention.